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KMID : 1007320130190020081
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Journal of the Korean Society of Menopause
2013 Volume.19 No. 2 p.81 ~ p.86
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Association between Serum Homocysteine Concentrations and Bone Mineral Density in Middle Aged Women
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Kim A-Ri
Lee Jun-Hee
Lee Ji-Young
Oh Young-Rim
Hong Sung-Nam
Choi Hoon
Jae Eun-Ae
Lee Hae-Hyeog
Kim Heung-Yeol
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Abstract
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Objectives: Hyperhomocysteinemia is known to be related with the early onset of osteoporosis. This study was to examine the association between serem homocysteine levels and bone mineral density (BMD) in middle aged women.Methods: The study included 409 women who underwent bone density tests in the health screening centers from January 2009 to october 2010. Serum homocysteine levels and BMD were measured.Results: Postmenopause group (n = 109) showed significantly lower BMD score in lumbar spine and femoral neck and significantly higher serum homocysteine concentration compared to premenopause group (n = 300). However, after adjusting for age, body mass index, and the menopausal condition in total 409 women, there were no significant correlations between serum homocysteine levels and BMD. Conclusion: Measurement of serum homocysteine levels may not be useful, but adjunctive for the risk assessment of osteoporosis in middle aged women.
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KEYWORD
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Bone density, Homocysteine, Osteoporosis
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